The Zambia Electronic Perinatal Record System (ZEPRS) is an Electronic Medical Record (EMR) system used by public obstetric clinics and the University Teaching Hospital in Lusaka, Zambia to improve patient care. The University of Alabama Birmingham (UAB) Center for Research in Women's Health  and the Center for Infectious Disease Research in Zambia (CIDRZ) developed ZEPRS with local medical expertise, and funding support from the Bill & Melinda Gates Foundation.

ZEPRS is one of the first of its kind EMR systems in sub-Saharan Africa. ZEPRS is helping medical personnel to improve care, combat the spread of HIV/AIDS, and manage records for perinatal patients and infants in clinics, the UTH, the Lusaka District Health Management Team, and the Ministry of Health. As of September 2011 ZEPRS contained medical records for more than 510,000 patients. ZEPRS was built using free and open source software (FOSS) products.