St. Louis Children’s hospitals
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$3.6 Million to Fund Personalized 3-D Brain Maps to Guide Neurosurgeries
Neurosurgeons must avoid cutting into parts of the brain responsible for key functions such as language (orange) and vision (green), but individuals vary in where such functions are located (each of the top images compared with the bottom images above). Researchers are creating a software program that uses data from MRI scans to create personalized anatomic and functional brain maps and integrate them into a navigational system to guide physicians during neurosurgery. Removing a brain tumor requires walking a fine line: Remove too little, and the disease remains; remove too much, and sight, speech or movement may be impaired...
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Study Unveils New Way to Starve Tumors to Death
For decades, scientists have tried to halt cancer by blocking nutrients from reaching tumor cells, in essence starving tumor cells of the fuel needed to grow and proliferate. Such attempts often have disappointed because cancer cells are nimble, relying on numerous backup routes to continue growing. Now, scientists at Washington University School of Medicine in St. Louis have exploited a common weak point in cancer cell metabolism, forcing tumor cells to reveal the backup fuel supply routes they rely on when this weak point is compromised. Mapping these secondary routes, the researchers also identified drugs that block them. They now are planning a small clinical trial in cancer patients to evaluate this treatment strategy...
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