drug resistance

Two important, linked publications are out today, both carrying the same message: The way we raise poultry in this country is creating an under-appreciated health hazard, and the government structures we depend upon to detect that hazard and protect us from it are failing us. Read More »

The Open Source Drug Discovery (OSDD) programme — a global collaborative initiative supported by the Indian government to find affordable treatment for neglected tropical diseases — has suffered a temporary setback due to a funds crunch caused by tardy submission of funding estimates. Read More »

Bio Model Analyzer, a Microsoft cloud-based tool that biologists can use to model cell interactions and communications, is now available as open-source on GitHub under a MIT license. Researchers use Bio Model Analyzer (BMA) to create computer models that can compare the processes within healthy and diseased cells. Researchers drag and drop cells, their contents (such as DNA or proteins), and extracellular components onto a canvas. They can also draw the relationships between these components...

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The 1960s was a decade that witnessed humans setting foot on the moon and a bloody war that changed the history. In between these events, a drug that would be the mainstay for doctors for decades to fight a smart bug, was born. Rifampicin was the last novel class of antibiotics against Mycobacterium tuberculosis till the arrival of bedaquiline at the fag end of 2012. Discovered in 1965, Rifampicin was marketed in Italy in 1968 and was approved by the US regulatory body in 1971...

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The superbug crisis is killing more patients than breast cancer as the Government is relying on flawed figures which mask the true scale of the problem, health experts have warned. The Department of Health estimates that 5,000 people die each year due to drug resistance, but Dr Ron Daniels, chief executive of the UK Sepsis Trust, claims the true figure is around 12,000. The number of deaths is rising each year as more bugs that lead to blood poisoning are becoming resistant to antibiotics...

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When people hear about antibiotic resistance creating “superbugs”, they tend to think of new diseases and pandemics spreading out of control. The real threat is less flamboyant, but still serious: existing problems getting worse, sometimes dramatically. Infections acquired in hospital are a prime example. They are already a problem, but with more antibiotic resistance they could become a much worse one. Elective surgery, such as hip replacements, now routine, would come to carry what might be seen as unacceptable risk. So might Caesarean sections. The risks of procedures which suppress the immune system, such as organ transplants and cancer chemotherapies, would increase...

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