Bryan Behrenshausen

Fibrodysplasia ossificans progressiva—more commonly called stone man's syndrome—is the result of a rare mutation, an anomaly in the way certain enzymes called kinases spur protein synthesis. Someone with stone man's syndrome has hyperactive kinases that catalyze more bone production than they should. The body's natural repair mechanisms malfunction, and they replace soft tissue with deposits of solid bone. Joints freeze. The body becomes a prison. But scientists know they can manipulate those kinases to combat the disease. And chemical biologists at the University of North Carolina are leading an open source effort to unlock the secrets of kinase activity—secrets they say could pioneer a new generation of drug discovery...

Nineteen years ago this week, at an annual meeting of Linux-Kongress in Bavaria, an American programmer named Eric Raymond delivered the first version of a working paper he called "The Cathedral and the Bazaar." According to Raymond, the exploratory and largely speculative account of some curious new programming practices contained "no really fundamental discovery." But it brought the house down. "The fact that it was received with rapt attention and thunderous applause by an audience in which there were very few native speakers of English seemed to confirm that I was onto something," Raymond wrote a year later, as his treatise blossomed into a book...